Description
We demonstrate high-sensitivity near-field infrared (IR) spectroscopy (nano-FTIR) for the label-free investigation of single cell cuts. We show that IR absorption of individual sub-cellular regions can be spectroscopically measured and small but consistent spectral differences can be resolved. This capability has the potential to pinpoint chemical changes at the cellular ultrastructural level when disease occurs. We will also discuss that nano-FTIR can be combined with synchrotron light sources for single-shot characterization of molecular vibrations but also phononic and plasmonic excitations in a large spectral range with nanoscale spatial resolution.
Primary author
Dr
Martin Schnell
