Joint Meeting of PSRS Members and SOLARIS Centre Users

Session

Session I - X-ray scattering in soft matter

Sep 11, 2024, 11:50 AM

SOLARIS Centre

Conveners

Session I - X-ray scattering in soft matter: Challenges of X-ray crystallography: Unusual molecular arrangements

• Mirosław Gilski

Session I - X-ray scattering in soft matter: Advanced software tools and workflows for synchrotron X-ray scattering analysis at ESRF from a user's perspective

• Maciej Jankowski

Session I - X-ray scattering in soft matter: Studies of the local structure of amorphous pharmaceuticals using X-ray scattering

• Karolina Jurkiewicz

59. Challenges of X-ray crystallography: Unusual molecular arrangements

X-ray macromolecular crystallography is a leading method for understanding the three-dimensional structure of proteins and nucleic acids. Despite the development of new research methods, such as Cryo-EM, crystallographic studies remain the most precise and reliable. However, some cases require unique procedures and deep structural analysis. These "difficult cases" are often abandoned after...

21. STUDIES OF THE LOCAL STRUCTURE OF AMORPHOUS PHARMACEUTICALS USING X-RAY SCATTERING

Low aqueous drug solubility in pharmaceuticals is a pervasive issue. It is estimated that around 70% of pipeline drugs in development today are poorly soluble molecules. Amorphization and formation of solid dispersions using crystalline structures of active pharmaceutical ingredients is one of the most effective methods to enhance their solubility and bioavailability as well as to reduce side...